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KMID : 0616120110420010061
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 1 p.61 ~ p.67
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Antidiabetes and Angiotensin Converting Enzyme Inhibitory Activity of Sonchus asper (L) Hill Extract
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Xu Ming-Lu
Wang Lan
Xu Gui-Fang
Wang Myeong-Hyeon
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Abstract
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In this study, we evaluated the bioactivities of methanol extract and its solvent fractions of Sonchus asper (L.) Hill. The EtOAc fraction of S. asper exhibited more strong antioxidant activity than other extracts as evidenced by the strongest 1,1- diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity with a EC50 value at 33.55 μg/mL and reducing power, the total polyphenol (180.71 mg GAE/g) and flavonoid contents (145.86 mg QE/g) of S. asper extract were higher than other extracts. The EtOAc fraction of the S. asper also showed 47.38% mushroom tyrosinase inhibition activity, 56.22% α-glucosidase inhibition and 46.58% α-amylase inhibition ratio at 1 mg/mL. Both methylene chloride and EtOAc fractions of methanol extract of S. asper effectively reduced of the 86.34% and 62.03% angiotensin I converting enzyme (ACE) activity at 2 mg/mL, respectively. These findings suggest that the EtOAc fraction of the S. asper could be a potential antioxidant in food additive, medicinal, and industry product.
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KEYWORD
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Sonchus asper, tyrosinase, α-glucosidase, α-amylase, ACE inhibitory activity
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